Clinical trial of malaria prophylaxis in tropical splenomegaly syndrome.
نویسندگان
چکیده
A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.
منابع مشابه
Hyperreactive malaria in expatriates returning from sub-Saharan Africa.
The extreme presentation of hyperreactive malaria is hyperreactive malarial splenomegaly syndrome (HMS). Some patients present with a less pronounced syndrome. To investigate whether the degree of splenomegaly correlates with the degree of immune stimulation, whether prophylaxis or recent treatment play a role, and whether short therapy alone is effective, we examined retrospectively the medica...
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Hyper-reactive malarial splenomegaly syndrome (HMSS) is a massive enlargement of the spleen due to an exaggerated immune response to repeated attacks of malaria. Tropical splenomegaly syndrome (TSS) is the most frequent cause of massive tropical splenomegaly in malarious areas [1-2]. It is seen more commonly among residents of endemic areas of malaria. It occurs mainly in tropical Africa, but a...
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متن کاملCONFERENCES AND MEETINGS Tropical Splenomegaly Syndrome
A one-day symposium was held at the Royal Postgraduate Medical School in London on 17 November. The participants comprised experts in tropical medicine, parasitology, pathology, immunology, and haematology, most of whom had had personal experience with splenomegaly in the tropics. They met to review the present state of knowledge and to define those areas where further research was likely to be...
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ورودعنوان ژورنال:
- British medical journal
دوره 1 5746 شماره
صفحات -
تاریخ انتشار 1971